The Jacobite uprising of 1745 was another poorly-led venture to get control of the inexhaustible riches. It finished with the defeat of the Catholics and the French, together with their Scottish supporters at the last military battle fought in our region.
The East West split of Highlands versus Lallands was a marked feature of whether Scots chose to favour Bonnie Prince Charlie or King George’s army led by his son The Duke of Cumberland - still known as "Bloody Cumberland" in Scotland (or "Butcher Cumberland" in polite English society and school textbooks) - who was supported at Culloden’s final victory by many lowland regiments.
The rebellion started in north-west Scotland, and had enough momentum to get as far south as Derby. (In the 1970's an old Derbyshire man told me that he called all Yorkshiremen “scotch rogues”, because some of their ancestors came south with Bonny Prince Charlie). The '45 belonged to an earlier time, Trade was the uprising, and Trade would eventually win.